Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students. Drawing on the latest research in this dynamic field, author Lauren Pecorino makes cutting-edge science readily accessible. Using the hallmarks of cancer as a starting point, the text looks at the cellular and molecular mechanisms underpinning the transformation of cells into cancer cells. After discussing the theory, each chapter then demonstrates how this knowledge can be directly applied to the development of new targeted therapies, giving students a clear appreciation of how the theory translates to tackling the disease. Molecular Biology of Cancer, Fourth Edition, features a variety of pedagogical features--"Pause and think," "How do we know that?," self-tests, and activities--to help students engage with, and master, the concepts presented. It provides students with a solid understanding of the essentials and an appreciation of how a theoretical understanding can be transformed into therapeutic benefit.A Companion Website contains resources for instructors--downloadable figures from the book and a test bank of multiple-choice questions--and related web links for students.
1. Introduction2. DNA structure and stability: mutations versus repair3. Regulation of gene expression4. Growth factor signaling and oncogenes5. The cell cycle6. Growth inhibition and tumor suppressor genes7. Apoptosis8. Stem cells and consequences of blocked differentiation9. Metastasis10. Angiogenesis11. Nutrients, hormones, and gene interactions12. Tumour immunology and immunotherapy13. Infectious agents and inflammation14. New technologies and drug development