Completely revised and updated, and for the first time in stunning full-color, Bacterial Pathogenesis: A Molecular Approach, Fourth Edition, builds on the core principles and foundations of its predecessors while expanding into new concepts, key findings, and cutting-edge research, including new developments in the areas of the microbiome and CRISPR as well as the growing challenges of antimicrobial resistance. All-new detailed illustrations help students clearly understand important concepts and mechanisms of the complex interplay between bacterial pathogens and their hosts. Study questions at the end of each chapter challenge students to delve more deeply into the topics covered, and hone their skills in reading, interpreting, and analyzing data, as well as devising their own experiments. A detailed glossary defines and expands on key terms highlighted throughout the book. Written for advanced undergraduate, graduate, and professional students in microbiology, bacteriology, and pathogenesis, this text is a must-have for anyone looking for a greater understanding of virulence mechanisms across the breadth of bacterial pathogens.
CHAPTER 1 The Power of BacteriaCHAPTER 2 Skin and Mucosa: The First Lines of Defense against CHAPTER 3 The Innate Immune System: Always on GuardCHAPTER 4 The Adaptive Defenses: Antibodies and Cytotoxic T CellsCHAPTER 5 The Microbiota of the Human Body: Microbiomes and BeyondCHAPTER 6 Microbes and Disease: Establishing a ConnectionCHAPTER 7 Mechanisms of Genetic Modification and Exchange: Role in Pathogen EvolutionCHAPTER 8 Identification of Virulence Factors: Measuring Infectivity and VirulenceCHAPTER 9 Identification of Virulence Factors: Molecular Approaches for Bacterial FactorsCHAPTER 10 Identification of Virulence Factors: Molecular Approaches for Host FactorsCHAPTER 11 Bacterial Strategies for Colonization and Survival in the HostCHAPTER 12 Toxins and Other Toxic Virulence FactorsCHAPTER 13 Delivery of Virulence FactorsCHAPTER 14 Virulence RegulationCHAPTER 15 Antimicrobial Compounds and Their TargetsCHAPTER 16 Antibiotic ResistanceCHAPTER 17 Vaccination: A Critical Component of the Modern Medical ArmamentariumCHAPTER 18 The Gram-Positive Opportunistic PathogensCHAPTER 19 The Gram-Negative Opportunistic PathogensCHAPTER 20 The Changing Roles of Microbiologists in an Age of Bioterrorism and Emerging Diseases