The new edition draws on the latest research in cancer biology, highlighting fundamental concepts and re-emphasising pre-existing concepts. The book features a variety of learning features - 'Pause and think', 'How do we know that?', self-tests and activities - to help students engage with, and master, the concepts presented. The emphasis is on acquiring a solid understanding of the essentials and an appreciation of how a theoretical understanding can be transformed into therapeutic benefit.

New to this Edition:

The inclusion of additional primary data from the literature provides up-to-date information about this dynamic field of research.

Figures to illustrate mechanisms of DNA repair.

New topics covered include extrachromosomal circular DNA as major sources of oncogene expression and tumor heterogeneity, the use of errors in RNA transcription and splicing as a new source of neoantigens for vaccines, the application of artificial intelligence to cancer imaging, and expanded applications of CRISPR, to name a few.

The expanded "Pioneers in the field" feature introduces students to thirteen inspiring molecular biologists working in the field from past to present.

Chapter 1 : Introduction

Chapter 2 : The cancer genome

Chapter 3 : Regulation of gene expression

Chapter 4 : Growth factor signaling and oncogenes

Chapter 5 : The cell cycle

Chapter 6 : Tumor suppressor genes

Chapter 7 : Apoptosis

Chapter 8 : Cancer stem cells and the regulation of self-renewal and differentiation pathways: focus on colon cancer and leukemias

Chapter 9 : Metastasis

Chapter 10 : Angiogenesis

Chapter 11 : Reprogrammed metabolism and diet

Chapter 12 : Tumor immunology and immunotherapy

Chapter 13 : Inflammation, infection, and the microbiome

Chapter 14 : Strategies and tools for research and drug development