PrefacePart I: The Classical Period, 1860-1940Prelude1. Overture: The Garden of Mendel2. Building a Scaffold: Genes Within ChromosomesPart II: One Gene-One Enzyme, 1900-1953Prelude3. The Dawn of the One Gene-One Enzyme Hypothesis during thClassical Period4. The Neurospora Era5. E. coli Enters the Field6. Biochemical Genetics in E. coli7. The Chemical Nature of GenesPart III: How Genes Determine Protein StructurePrelude8. Building a Theoretical Framework for Gene Action9. Biochemical Identification of Adaptors10. The Elusive Messenger11. Deciphering the CodePart IV: Regulation of Gene ActionPrelude12. Feedback Control of Biosynthetic Pathways13. Adaptive Enzymes14. The Operon ModelPart V: The Aftermath of the Operon ModelPrelude15 The Floodgates Open.AppendixFurther Readings