Preface 
 Preface to the First Edition 
1 The Role of Genetics in Medicine 1
2 Structure and Behavior of Genes and Chromosomes 9
3 Mendelian Inheritance 23
4 Population Genetics and Multifactorial Inheritance 43
5 Molecular Genetics: Gene Organization, Regulation, and Manipulation 61
6 Molecular Genetics of Human Disease: Hemoglobinopathies 91
7 Biochemical and Molecular Genetics of Human Disease 117
8 Cytogenetics 153
9 Anatomy of the Human Genome: Gene Mapping, Linkage and Positional Cloning 195
10 The Human Genome Project 231
11 Cancer Genetics 245
12 Clinical Genetics 273
13 Gene Therapy 311
14 Ethical Considerations 329
 Glossary 341
 Study Questions and Answers 351
 Index 395