Chapter 1: The photosynthetic reaction centre: protein structure in a microcosm
The reaction centre from Rhodopseudomonas viridis
Conclusions
Recommended reading and references
Exercises and problems
Chapter 2: In vivo, in vitro, in silico
Why study proteins?
Protein structure and conformation
The known protein sequences
The protein data bank
The World-Wide Web
Summary
Glossary
Useful Web sites
Recommended reading and references
Exercises, problems and weblems
Chapter 3: Pattern and form in protein structure
Helices and sheets
The heirarchical nature of protein architecture
An album of small structures
Classification of protein structures
Loops
Protein-ligand interactions
Useful Web sites
Recommended reading and references
Exercises, problems, and weblems
Chapter 4: The varieties of protein structure
Catalogues of protein structure
The known structures
alpha-helical proteins
beta-sheet proteins
alpha + beta proteins
alpha/beta proteins
Closed beta-alpha-beta barrel structures
Irregular structures
Conclusions
Useful web sites
Recommended reading and references
Exercises, problems, and weblems
Chapter 5: Molecular evolution
Evolution of protein structures
Structural relationships among related molecules
Useful web sites
Recommended reading and references
Exercises, problems, and weblems
Chapter 6: Evolution in selected protein families
Evolution of the globins
Evolution of serine proteinases of the chymotrypsin family
NAD-binding domains of dehydrogenases
Useful web sites
Recommended reading and references
Exercises, problems, and weblems
Chapter 7: Some proteins of the immmune system
Antibody structure
Proteins of the Major Histocompatibility Complex
T cell receptors
Useful web sites
Recommended reading and references
Exercises, problems, and weblems
Chapter 8: Conformational changes in proteins
Structural changes arising from change in state of ligation
Hinge motions in proteins
The helix interface shear mechanism of conformational change
The allosteric change in haemoglobin
Serpins: SERine Proteinase Inhibitors
Higher-level structural changes
Index
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