INDEX

 UNIT I: Introduction
1.The Cancer Cell
UNIT II: Viral Oncogenes
2. Tumor Viruses
3. Retroviral Oncogenes
4. The Origin of Retroviral Oncogenes
UNIT III: Cellular Oncogenes and Tumor Suppressor Genes
5. Identification of Cellular Oncogenes by Gene Transfer
6. Cellular Oncogene Targets for Retroviral Integration
7. Oncogenes and Chromosome Translocation
8. Amplification of Oncogenes in Tumors
9. Discovery of Tumor Suppressor Genes: The Retinoblastoma Prototype
10. Tumor Suppressor Genes in Human Neoplasms
11. Role of Oncogenes and Tumor Suppressor Genes
UNIT IV: Functions of Oncogenes and Tumor Suppressor Genes
12. Oncogenes and Growth Factors
13. Protein-Tyrosine Kinases and Growth Factor Receptors
14. Guanine Nucleotide Binding Proteins
15. Protein-Serine/Threonine Kinases
16. Transcription Factors
17. Pathways of Mitogenic Signal Transduction
18. Regulation of the Cell Cycle
19. Development, Differentiation, and Programmed Cell Death
UNIT V: Clinical Applications
20. New Prospects for Cancer Prevention and Treatment